In a post-apocalyptic 2019, Rogan went missing following a mission at the EFI Research Facility. Two weeks later, Lisa -- determined to find her father -- arrived with "G", Rogan's retired partner, at the undead-infested facility where contact with him was lost.
Lisa and "G" eventually found Rogan, who revealed that he was rescued by Dr. Roy Curien's son Daniel. They also learned that Curien's body had been undergoing a 19-year resurrection process; he was to transform into The Wheel of Fate, a powerful entity. Daniel, disgusted by his father's crimes, vowed to stop him.
While "G" stayed behind to care for Rogan, Lisa and Daniel fought to the Wheel of Fate's chamber; they eventually defeated Curien, thus rescuing the last of humanity from extinction.
Lisa is dedicated and persistent, having vowed to her mother that she would bring her father Rogan home. While serious, she occasionally makes humorous quips in combat; for instance, after defeating the mutant tree Sun, she remarks that she "was never good at gardening."
Lisa and her father have a strained relationship; she notes that he "always put work ahead of his family" and has hardly any memories of him spending time with her and her mother. She is also annoyed by her father constantly telling her to "believe in [herself]", to point of wanting to "smack him upside the head for Mom!"
Despite this, Lisa is overjoyed when she finally reunites with him, at last understanding what "believe in yourself" truly means to her. She takes responsibility, ordering "G" to look after her wounded father and expressing determination to continue fighting for him.
- Lisa is the first playable female character in the main series (the second being Kate Green from The House of the Dead 4). This is not counting Linda Rotta from the spinoff Zombie Revenge, which predates The House of the Dead III.
- Lisa's real middle name is "Richards" (or R.) because her mother is confirming to be a Richard surname like Sophie's name to be changed (Sophie R. Rogan).